Autism Treatment – MAO-A Activity, and Its Benefits As an Autism Treatment, Part 1 of 2

Posted on 09 January 2011 by admin

This is part 1 of a 2 part series on the MAO-A activity of Respen-A in autism treatment but I wanted just to clarify real quickly, I think I misspoke on the previous recording. The name of that journal which was published in 1957 is The Journal of Nervous and Mental Disease by Dr. Lehman and others so if you want to reference that it is The Journal of Nervous and Mental Disease by Dr. Lehman in 1957. This is the study that was using 3 – 7 mg dosages of Reserpine in Autistic children with many of the improvements that I mentioned before. The nonverbal communication, the eye contact, the less self stimulatory behavior, the increased socialization, etc.

MAO-A Activity with Autism Treatment

Let me talk a little bit about what Reserpine does. There is an enzyme called Monoamine Oxidase A (MAO-A). This is an enzyme found within the cells that is important to help metabolize 3 primary neurotransmitters, histamine, serotonin and nor epinephrine. Reserpine is a known MAO-A agonist. Now there have been a lot of people who have commented in autism treatment that Respen will deplete MAO-A or inhibit MAO-A activity. Respen, and Reserpine, is not an MAO-A inhibitor. There are medications that inhibit MAO-A activity and they are used many times for depression but Reserpine is not one of them. It actually augments the metabolic capacity or the enzyme capacity of MAO-A activity.

And in doing so what it does is it turns serotonin over into what’s called its active aldehyde form. So that active aldehyde form, the 5 hydroxyindole acetaldehyde then complexes that post synaptic receptor to have the physiological effect on that post synaptic neuron. Now in doing so, you can lead to a problem of depleting serotonin over time by using either high doses of Reserpine in autism treatment or even the Respen-A which is at a very low dose if protein or if serotonin is not being replenished.

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