Archive | January, 2011

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Autism Treatment – Herxheimer Reactions and Autism

Posted on 25 January 2011 by admin

Autism Treatment – Herxheimer Reactions

In autism treatments, we’ve often heard of die off reactions when dealing with yeast or bacterial problems. In classical medical terms, this is called a Herxheimer reaction. A Herxheimer reaction was originally used to describe a treatment reaction for individuals with syphilis. We also hear about it in the Lyme community, certain parasites can cause a die off or a Herxheimer reaction as well. And typically when we’re thinking about the yeast die off, or a yeast Herxheimer reaction, many times we’ve seen increase in the symptoms that yeast can cause, whether it’s self stimulatory behavior, sensory issues, goofiness, giddiness, silliness, inappropriate laughter.

If it’s bacterial problems for many kids on the spectrum who are neurologically sensitive to these organisms, it may be irritability, aggression, self injurious behavior, just moodiness, some kids who have bacterial problems have tics so whatever it may be, that primary thing that’s going on. Sometimes when you start treating for those infections, those symptoms can actually get worse before they get better. There’s been a lot of discussion on autism treatment on how to deal with this.

Autism Treatment Dealing with Herxheimer

One of the things that can help sometimes is activated charcoal. Activated charcoal is a binding agent that is taken orally, will help to absorb those toxins in the digestive tract and prevent them from being absorbed. Usually a capsule or two a day does the trick. A capsule, anywhere between 250 – 300 mg tends to do the trick sometimes helping to short circuit those die off reactions. Another thing that can be done in autism treatment, and really it’s only going to work in a child who can actually tolerate things like lemon and lime, you can actually take a lemon and you can take a lime and you squeeze it into some water. About 8 ounces of water and have them sip that throughout the day, maybe every 15 minutes or so, through a straw. And what those two foods do, in the juice actually is creates a PH shift. It actually helps the body become more alkaline, less acidic and that can actually help diminish, and sometime stop, that die off reaction. But again, it’s only going to be tolerated in kids that would drink that.

But I just wanted you to be aware that it’s one of the things that you can use sometimes to short circuit that die off reaction. We’ve used this quite a bit with individuals who are undergoing intensive therapy for Lyme disease who get the joint aches, the fever, fatigue, using that lime and lemon trick often works. It may work for you with your child as well in to these autism treatment.

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Autism Treatment – Respen-A, Supplement Avoidance and Autism

Posted on 25 January 2011 by admin

In part 2 of this 2 part series on autism treatment using Respen-A, we will discuss other recommended supplements to stop while using Respen-A. There’s also been a discussion about high dose antioxidants. Again, another issue is a lot of kids on the Autism spectrum have, they’re just too much oxidative stress going on, so they’re on a lot of supplements. But there’s always that potential whenever a child is on a lot of supplements, a lot of antioxidants, that they may be getting too much and it’s hard to know sometimes it’s very difficult for a doctor to absolutely know how much supplement any one child needs, even the testing sometimes is inconclusive. So the rule of thumb with Respen-A autism treatment has been, if at all possible, is try and reduce the amount of supplements your kids are on just so we initially before starting so we can really try to get a true read on how well this therapy is working and then it can be adjusted later, it can always be added back later.

Autism Treatment With Respen-A

Because it has been found that too many antioxidants may have somewhat of an inhibiting effect. It’s not that these supplements have a toxic effect, but they just seem to inhibit some of the positive benefit that we see with Respen-A. High dose vitamin D is something that is quite popular in the Autism community clearly there’s a number of kids that seem to show deficits in vitamin D, and there’s been some discussion about modifying the vitamin D dosing because of the Respen-A therapy as well as a few other supplements like B6 or GABA or whatnot. The main one that I have seen in my practice clinically, that I can really with confidence say that I feel has inhibited the positive, the early benefits of Respen-A have been the essential fatty acid supplements and so when I start a child off on this form of autism treatment, I really check to make sure if they’re on it and we try to wean them off or get them off it at least three weeks prior to starting the autism treatment.

Respen-A Could be the Autism Treatment For You

Like I mentioned before, it takes about three weeks to see some of the positive influence of being off that supplement and seeing the positive influence of the Respen-A. So, again, there’s always more to learn and as a parent or if you’re a physician watching this, I really encourage you to study this to research this more. As I mentioned in the last video, there is a Facebook page now that is available for Respen-A that you can post questions to and I also have a tremendous amount of information on my membership site at www.AutismActionPlan.com and that’s a place that you can reach me as well and ask questions with respect to more things regarding my clinical experience in using this autism treatment.

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Autism Treatment – Respen-A, Essential Fatty Acids and Autism

Posted on 24 January 2011 by admin

In autism treatment, I’m often asked about some of the other supplement recommendations that are being recommended when kids go on Respen-A and this too has created some controversy within the biomedical community. And like any new therapy there’s always going to be people who question it and whatnot and that’s a healthy thing actually. Whenever new information is presented or new therapies are presented, there’s a lot of questions to ask and these questions need to be answered. So that’s appropriate and I have no problem with that.

Essential Fatty Acids as Autism Treatment

When I first started using this treatment, the main recommendation that was used was to stop essential fatty acid supplements, cod liver oil, fish oil, borage oil, evening primrose oil, whatever it was. And initially I had some difficulty with that because I’ve seen a lot of kids get benefit from essential fatty acid supplements, and we know that many kids on the Autism spectrum have problems with their diet, very limiting in what they eat and they may not be getting enough nutrients. So adding in essential fatty acids as autism treatment for a lot of kids has been helpful.

Cod liver oil has been helpful we know for a lot of visual issues and visual stimulation problems that kids have had and I’ve clearly seen them in my practice too where a lot of times kids visual stimming diminishes or completely goes away when they’re on cod liver oil. When I first started using Respen-A, I wasn’t taking kids off of fish oil, and some kids seem to do fine, some parents took their kids off the supplements anyway, but I was sort of approaching it with “well let’s go ahead and let it stay there and we’ll change it later if we need to”. I then started running into situations where I was recognizing that certain kids clearly weren’t getting the early benefit that I was hoping to see. And so, reluctantly, early on I went ahead and said “hey, let’s at least take that supplement out and let’s see how we do with this Respen-A as autism treatment can always add it back”.

Autism Treatment – How Respen-A, Essential Fatty Acids Works

Well, what I’ve recognized is there is a difference in how Respen-A works when a child is on an essential fatty acid product and when they’re not. It just seems to, in the majority of cases, it seems to work better. It’s not to say that it doesn’t work in some kids who are on essential fatty acid supplements, the vast majority of kids it does seem to work better. Now I’ve had some kids who we took off of the essential fats in autism treatment, and it seems to be about a three week time frame, by the way, of when they need to come off. We start it and maybe a couple months later we add it back and there’s been some kids that it did not have a detrimental drop in their benefits so I’m ok with that. Like anything, all kids, they’re all individuals, they’re all different, no two usually react exactly the same way to any autism treatment.

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Autism Treatment – Stopping biomedical treatments and Autism

Posted on 23 January 2011 by admin

Let’s talk a little bit about biomedical therapies in autism treatment, especially stopping and starting therapies. I’m often asked the question “my child’s taking B12 or my child is on Nystatin or Diflucan or they’re on various supplements, can they be stopped all of a sudden or should we wean off of these therapies?”. In my experience, the bulk of biomedical therapies that are given, if there is a plateauing, and you’re seeing no longer improvement in the initial benefits that you saw, it’s perfectly appropriate, and certainly work with your doctor on this, but in my experience, to stop those therapies without any ill effects.

Correct Time to Stop Biomedical Autism Treatment

And what I mean by that is there are certain medications, steroid medications, anti-depressant medications and other types of psychiatric medications that many times need to be weaned which means you need to back off slowly, so you’re transitioning from one dose to the next. But for B12, anti-fungal therapy, most supplements, that just isn’t the case, at least in my experience. So it’s not like there has to be a weaning process for all of these therapies but of course it’s something you want to work with your physician on just to make sure. But I’m often asked that in my practice “can my child stop B12 all of a sudden or do we need to wean it down?” No, in my experience, if it’s time to stop it, if it seems appropriate to stop it, it can just be stopped and then certainly restarted at a later time for autism treatment.

So, the bulk of therapies are like that. There’s not dangerous reactions that are going to occur, we’re not putting kids on highly toxic substances here, or highly stressful medications. Certainly as I mentioned some of the medications like that if there’s ever a question about that you certainly need to work with your doctor and ask them but the bulk of biomedical therapies the things that kids are typically on from supplements, the anti-fungals and whatnot, if they need to be stopped, they generally can be stopped right away without having to wean off of them as autism treatment.

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Autism Treatment – Respen-A, Calcium Supplementation and Autism Treatment

Posted on 17 January 2011 by admin

Autism Treatment – Reserpine and Respen-A Side Effects

A lot of people have asked about some of the side effects of Reserpine and Respen-a in biomedical autism treatment. Clearly with Reserpine, remember those studies that was done in autistic children in 1957 they were using three to seven milligrams, when the levels got too high, kids became irritable, they became cranky, many of them had excessive sleeping, dry mouth and started to develop actually symptoms of parkinsonism when the levels got way high; ten to twelve milligrams. In levels above what would typically for high blood pressure which is point five milligrams, so above point five milligrams there seems to be an increase association with depression. The reason that would be likely is that you’re stimulating MAO-A activity which is having a metabolic effect on serotonin so therefore you’re over time you’re depleting serotonin levels and if they’re not being replenished than clearly there can be a problem with respects to serotonin balance in the body and clearly there can be a problem leading to depression.

Most of the side effects of Respen and Reserpine seem to likely have to do with low blood calcium. Irritability, agitation, crankiness, within kids muscle aches, fatigue, these types of things which can be associated with low blood calcium. Matter of fact, it was the Respen-A people that really first determined that calcium needed to be taken with Respen-A to help counter some of these side effect issues which were commonly seen with Reserpine at higher dosages and honestly have been seen with Respen-A when kids are not getting enough calcium. One of the things that has come out as well in autism treatment is the use of calcium at a high dose for kids and individuals who are taking Respen-A, and this has been a concern for some doctors in the community. And honestly, I had some questioning about it early on when I first started using this therapy because the general recommendation is use 2,000 mg of calcium in the morning minimally thirty minutes prior to treatment upwards of forty five or sixty minutes before putting the Respen-A patch on to try to get the blood levels of calcium up because it is known that Reserpine can deplete blood calcium levels and this can lead again to some of the irritability, the agitation, the muscle aches, the twitching, and whatnot, the cramps that we have seen. And I have seen this with some kids who were taking this therapy as autism treatment when they weren’t getting enough calcium.

Calcium Supplementation as Autism Treatment

Now, you know that in autism treatment there always is a concern about the potential for too much calcium you’ll lead into calcium imbalances in the body. To date, through my practice, I have seen no issues whatsoever with an over absorption or an over abundance of calcium and this is through checking blood tests, looking at certain calcium levels etc. I have not seen a problem, nor has there been any reported to me from other physicians using this treatment. Nor the individuals at Respen-A have they reported any problems with taking this much calcium.

Now I have had a few kids who have a great intolerance to calcium and that’s a different story, but never have I not seen any blood evidence of it or physiological evidence of calcium toxicity through this therapy. It may have to do with the sure fact that the Respen is having a regulating effect over this calcium and keeping things in the more balanced fashion. So, that’s why the calcium issue in autism treatment has come up is because they had found that there’s a depleting effect on cellular calcium and the need to take calcium along with this therapy to prevent some of those common side effects of irritability, agitation, that can be found with calcium depletion.

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Autism Treatment – Respen A, Reserpine and Cancer

Posted on 11 January 2011 by admin

Some people have brought up the concern in autism treatment about Reserpine being associated with cancer. There were some early studies using rats and mice that actually showed that Reserpine led to an increase in what was called mammary tumors, seminal vesicle tumors, as well as tumors of the adrenal glands. In these rats and mice though, they were using dosages of Reserpine a hundred times more than was being used by any human, particularly people who were using Reserpine for high blood pressure remember that was a point one to point five milligram dose.

Using Reserpine for High Blood Pressure in Autism Treatment

In autism treatment, there were about three studies that came out that showed a link between Reserpine in women who were using Reserpine for high blood pressure, but in 1985 in the annals of internal medicine there was an article that reported nine additional studies that refuted those claims and they actually pointed to flaws that indicated those earlier studies pointing to a link of Reserpine were in error. At this point, there appears to be no indication that Reserpine at the doses that were used for high blood pressure and certainly the dosages that are the doses being used in Respen-A have any indication of increased cancer risk. Matter of fact,in autism treatment Reserpine has been shown to not only have a positive influence on hepatic cancer, but in early colon cancer it seems to be useful as well and may even be preventative for colon cancer, so the reverse is true, that Reserpine, in moderate dosages may have a beneficial influence on those particular types of cancers.

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Autism Treatment – Respen-A, Pharmacies, Prescriptions and Autism Treatment

Posted on 10 January 2011 by admin

A number of people undergone autism treatment have asked is Respen, Respen-A, Reserpine, a homeopathic medication. What Reserpine is listed not only as an allopathic drug, but through a system called the HPUS as a homeopathic medication. Now the dosages in Respen-A are considered of a homeopathic range. Now there may be some arguments in the autism treatments that happen between conventional homeopaths and whatnot but the dosages typically listed in the Respen-A of .01 milligrams are considered homeopathic at least through the HPUS system.

Explanation of a Prescription in Autism Treatment

Now, it is a prescription item and the reason it’s a prescription item is it’s not currently manufactured which means it has to be compounded. So any medication, even if you add a flavoring to it, so if you take Nystatin for example; and you have a powder and you want it created in an oral suspension, you have to add flavoring to it by definition, that would be a prescription item, or would need to be compounded through a compounding pharmacy. If you took Aspirin, which is over the counter, and wanted to have it turned into an oral Aspirin, for example, that would by law be a prescription item because it’s being altered, flavoring is being added to it, making it an oral suspension, therefore making it a prescription item. So, it is a prescription item, it does need a doctor’s prescription because it’s not being manufactured it has to be compounded and prepared therefore it has to be prepared through a compounding pharmacy.

Pharmacies that Dispense Respen-A with Autism Treatment
There are a number of pharmacies around the country now that are using it as an autism treatment, the main one up in Washington, called Custom Prescription Shoppe, is dispensing it. There are a few others, Hopewell Pharmacy, I know in New Jersey is dispensing it, Wellness Pharmacy down in Alabama is dispensing it and there may be a few others at this recording that are prescribing it as well that I’m not aware of and there may be certainly in the future, others that are using it being that this is recording in October of 2010, but primarily right now, there’s three main pharmacies that are dispensing Respen-A and I believe there’s also one in Canada as well. So if you want to find out a pharmacy in your area, you can go to www.respen-a.com.

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Autism Treatment – MAO-A Activity Benefits and Autism, Part 2 of 2

Posted on 10 January 2011 by admin

This is the 2nd part in this autism treatment series of videos on Respen-A and MAO-A activity. So some of the side effects that have actually been observed and I have seen them in my practice, not common but I have seen that where kids are not getting enough protein, is they can become more emotionally, they can have start to have these meltdowns, they become more attached. They may have difficulty in transitioning and this usually sometimes manifests as problem where their serotonin levels are becoming depleted and what we need to do is either give things like 5-HTP and in some cases give tryptophan to try and bolster the serotonin levels up. But this is very rare. I always caution my parents before implementing this in autism treatment we need to make sure the child is eating protein, eating some meat in their diet and that usually is enough. But on the rare occasion there have been a few kids that were so picky and so limited in their diets that we’ve had to supplement with 5-HTP or even tryptophan occasionally just to make sure their serotonin levels don’t become depleted.

Effects of MAO-A in Autism Treatment

Now MAO-A can be inhibited from a number of things. We know that through the use of pitocin as an agent to help with delivery can have an effect on this system. We know that excess estrogen can have an adverse effect on this system. Lipid peroxides and oxidative stress, certainly heavy metals like mercury and cadmium and arsenic can have a detrimental effect on this system as well. So there are a number of things that are common in the Autism Treatment community that we are commonly treating, heavy metals for example or oxidative stress for example. There’s other factors too.

There’s nothing in the traditional biomedical community or treatment or approach that is any different than how we might approach this particular system, its just another system that’s being negatively impacted in Autism. There’s also another monomine oxidase that is called monomine oxidase B (MAO-B) and that primarily has an impact on dopamine. And what can happen is, if MAO-B activity is too high it can tend to have a suppressive effect on MAO-A. So it is the balance between MAO-A and MAO-B that is important in autism treatment and when we have a deficit in this MAO-A activity this is really where something like Respen-A would be very helpful.

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Autism Treatment – MAO-A Activity, and Its Benefits As an Autism Treatment, Part 1 of 2

Posted on 09 January 2011 by admin

This is part 1 of a 2 part series on the MAO-A activity of Respen-A in autism treatment but I wanted just to clarify real quickly, I think I misspoke on the previous recording. The name of that journal which was published in 1957 is The Journal of Nervous and Mental Disease by Dr. Lehman and others so if you want to reference that it is The Journal of Nervous and Mental Disease by Dr. Lehman in 1957. This is the study that was using 3 – 7 mg dosages of Reserpine in Autistic children with many of the improvements that I mentioned before. The nonverbal communication, the eye contact, the less self stimulatory behavior, the increased socialization, etc.

MAO-A Activity with Autism Treatment

Let me talk a little bit about what Reserpine does. There is an enzyme called Monoamine Oxidase A (MAO-A). This is an enzyme found within the cells that is important to help metabolize 3 primary neurotransmitters, histamine, serotonin and nor epinephrine. Reserpine is a known MAO-A agonist. Now there have been a lot of people who have commented in autism treatment that Respen will deplete MAO-A or inhibit MAO-A activity. Respen, and Reserpine, is not an MAO-A inhibitor. There are medications that inhibit MAO-A activity and they are used many times for depression but Reserpine is not one of them. It actually augments the metabolic capacity or the enzyme capacity of MAO-A activity.

And in doing so what it does is it turns serotonin over into what’s called its active aldehyde form. So that active aldehyde form, the 5 hydroxyindole acetaldehyde then complexes that post synaptic receptor to have the physiological effect on that post synaptic neuron. Now in doing so, you can lead to a problem of depleting serotonin over time by using either high doses of Reserpine in autism treatment or even the Respen-A which is at a very low dose if protein or if serotonin is not being replenished.

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Autism Treatment – Respen-A dosages and Autism

Posted on 02 January 2011 by admin

What is Respen-A in Autism Treatment

Now some parents have been asked and been concerned about the fact that Respen-A in autism treatment contains an ingredient that is from a drug, and that is true. The active ingredient in Respen-A is something called Reserpine. Reserpine comes from an Indian herb called snakeroot and the name of it is rauwolfia serpentina. In 1955 the FDA approved Reserpine for the treatment of hypertension. Now Reserpine isn’t really being used for hypertension anymore, or if it is not to a significant degree. There are too many other high blood pressure medications now, but it was approved for that purpose. The dosage range that was used was .1 – .5 mg, the actual amount of Reserpine found in Respen-A is .01 mg so you are talking about 10 to 50 times less Reserpine in Respen-A than was found in the other forms of Reserpine for high blood pressure.

Treatment Dose of Respen-A in Autism Treatment

Now in the Autism community, Respen-A was first introduced around November 2008 and there was a small study that was done tracking some kids over about a year between November 2008 to November 2009. The results were quite promising so a press release was released based on this treatment and parents started using it. Now in 1957 in the Journal of Mental Disorder and Disease, there was actually a study that was using Reserpine in a group of Autistic children. They were using an oral elixir between 3 – 7 mg as a dose. Now think about that, the treatment dose for hypertension through the FDA approval was .1 – .5 mg in this journal back in 1957 they were using 3 – 7 mg as an oral elixir in Autism. And what they found was in these groups of kids much better communication from the verbal standpoint, eye contact, much less self stimulatory behavior, better socialization, improved general awareness, willingness to play, willingness to socialize, etc. The same types of things we are seeing who are doing the Respen-A therapy and honestly the same types of things I see with other therapies like Methyl B-12.

Some kids in autism treatment have side effects of excessive sleepiness, some have dry mouths, nothing that was too significant. When they pushed the doses upwards of 10 – 12 mg some kids started to take on some adverse neurological behaviors, kids sort of manifesting like with Parkinson’s and Parkinsonian’s type symptoms. But again we are talking between 200, 300 – 700 times the amount that was actually used in that research study back in 1957 and what’s being used today through the Respen-A patch. So the dosage ranges are not even close but the overall benefit that’s being seen is. So again the eye contact, the socialization, the general awareness, the improvement in speech quality, that appropriateness of speech, the deliberateness of speech those are the main things that I have seen in my practice in biomedical autism treatment. So I want to get that out there because there has been a lot of misconception about what Respen-A does in autism treatment and when comparing the actual amount of Reserpine in Respen-A to the amount that was in medications for high blood pressure and even the amount that was used in the earlier study in 1957.

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